Antitumor相关论文
40. The in vitro Inhibitory Effects of Acanthopanax Giraldii Harms Var. Hispidus Hoo Plant Polysacch
...
Human β-defensin-2 Enhances Anti-tumor Efficacy of Survivin-based Broad-spectrum DNA Vaccine in Mous
Objective: Malignant tumors greatly endanger and affect the quality of human life. Among antitumor biotherapy strategies......
Lung cancer is one of the leading causes of cancer-related death worldwide.Various therapeutic failed in the effective t......
Sinomenine (SIN) is a bioactive alkaloid compound extracted from a Chinese medicinal plant Sinomenium acutum.It is a mul......
Cancer is one of the most serious diseases that endanger human health.The mortality rate is only second after cardiovasc......
Biological evaluation of redox-sensitive hyaluronic acid micelle as a new nano-carrier for intraveno
An amphiphilic hyaluronic acid derivate,redox-sensitive hyaluronic acid-deoxycholic acid(HA-ss-DOCA)conjugate,was succes......
Water-soluble conjugated polymers (CPs) provide a unique platform for chemical and biological sensors in view of their o......
Context:Liver cancer is common in developing countries and it is the most common cancer type in some countries....
Phyllanthusnirusi L.,a well-known medicinal plant,has been used as a folk antitumor remedy in the worldwide scale.Howeve......
...
DCZ0801,a novel compound,induces cytotoxicity and cell cycle arrest in Diffuse large B-cell lymphoma
...
p21-activated kinases(PAKs)are a family of serine/threonine kinases that act downstream of Rho GTPases,Rac and Cdc42....
Gossypol,a natural product isolated from cotton seeds and roots,binds to Bcl-2 and Bcl-x with quite high affinities that......
In recent years,there are many reports of anticancer activities of artemisinins both in vitro and in vivo[1].Carbonic an......
Histone deacetylase(HDAC)has emerged as an attractive target for the development of antitumor agents during the past dec......
Novel Histone Deacetylase(HDAC)Inhibitors Equipped with Phenylsulfonylfuroxan Module as Nitric Oxide
Based on the strategy of “multifunctional drugs”,a novel series of phenylsulfonylfuroxan-based hydroxamates with histo......
Liaoqiao aqueous extract inhibits B16 melanoma growth involving MAPKs/Nrf2/HO-1 mediated anti-oxidat
Aim Forsythia suspensa (Thunb.) Vahl, Lianqiao in Chinese, is one of the most fundamental herbs in traditional Chinese m......
...
SL-01,dodecyl-3-((1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidi......
Remote and Noninvasive NIR-Ttriggered DOX Release from DOX/ICG-Loaded Temperature-Responsive Nanopar
Smart nanoparticles (NPs) that respond to external stimulations, including light, hyperthermia,reduction/oxidation and u......
NMMP displays antitumor activity through inhibition of proliferation and induction of apoptosis in h
6-[(1-naphthylmethyl)sulfanyl]-9H-purine (NMMP) is a derivative of 6-Mercaptopurine.We have demonstrated that NMMP reduc......
c-Met is one of receptor tyrosine kinase,expressed in normal and tumor cells are present [1].In human cancers,c-Met sign......
Design,synthesis and biological evaluation of novel thiopyrano[4,3-d]pyrimidines as PI3K/mTOR inhibi
...
Stel B (Stellettin B) was isolated from marine sponge Jaspis stellifera.In vitro antitumor activities were investigated ......
...
Traditional therapy aimed at changing tumor microenvironment makes efforts on reducing tumor vessel density to control i......
Objective: In this study, we sought to investigate the role of AT101 on cell viability of human esophageal cancer cells ......
Inhibitory effect of plumbagin, a potential anticancer natural compound, on cytochrome P450 2J2 in h
OBJECTIVE Cytochrome P450 (CYP) 2J2 is highly expressed in many kinds of human tumors and promotes tumor cell growth via......
目的 对镰形棘豆的二氯甲烷部位进行化学成分研究。方法 采用硅胶柱层析的方法，并结合 MS 和NMR 等波谱技术对所得化合物进行结构鉴......
Purpose: The main purpose of this study was to investigate the active components of the Chinese medicine formula Shenqi ......
Targeting the WEE1 kinase strengthens the antitumor activity of imatinib via promoting KIT degradati
Objective Gastrointestinal stromal tumor(GIST)is the most common mesenchymal tumors of the gastrointestinal tract and or......
Until now, there is not yet antitumor drug with dramatically improved efficacy on non-small cell lung cancer (NSCLC).Mar......
Aim Nicotinamide phosphoribosyltransferase (NAMPT) is a promising therapeutic target for cardiocerebrovascular diseases ......
Jaridonin, a novel ent-kaurene diterpenoid compound from Isodon rubescens,promotes cancer cell death
AIM Reeently, we isolated a novel ent-kaurene diterpenoid compound, from Isodon rubescens, named Jaridonin.The current s......
Stel B (Stellettin B) was isolated from marine sponge Jaspis stellifera.In vitro antitumor activities were investigated ......
Evaluation of pluronic nanosuspensions loading a novel insoluble anticancer drug both in vitro and i
Aim: The aim of this study was to prepare a nanosuspension loading a novel insoluble anticancer drug (Q39) by precipitat......
...
A water-soluble polysaccharida named as HPS-1 was isolated from the roots of Hedysarum polybotrys Hand.-Mazz by hot wate......
Synthesis and the Interaction of 2-(1H-pyrazol-4-yl)-1H-imidazo[4,5-f][1,10]phenanthrolines with Tel
A novel series of 2-(1H-pyrazol-4-yl)-1H-imidazo[4,5-f][1,10]phenanthrolines were designed,synthesized and evaluated for......
Platinum-terpyridine complexes have been receiving increased attention in bioinorganic and medicinal chemistry due to th......
...
Glucose transporters(GLUTs) as carriers catalyzing the facilitative diffusion of glucose across the membrane into the ce......
Cancer has become the first killer of human health.The investigation of effective chemotherapeutic agents is a hot topic......
Many reported aptamers are G-rich oligonucleotides(GROs),which bind their targets based on the G-quadruplex structures....
DNA origami directed in-situ combination of chemotherapy and gene therapy with enhanced antitumor ef
Malignant tumor is one of the most serious diseases that affect human health.As patients with long-term chemotherapy,mul......
Alkylation of phosphorothioated thrombin binding aptamer improves the selectivity of inhibiting tumo
Aptamers are recently extensively researched for therapy and diagnostic,thrombin binding aptamer is a 15nt deoxyribonucl......
Imperatorin suppresses proliferation and angiogenesis of human colon cancer cell by targeting HIF-1α
Imperatorin is an active natural furocoumarin component originating from the traditional Chinese medicine Angelica dahur......
Design,Synthesis and Antitumor Activity of Novel link-bridge and B-Ring Modified CA-4Analogues as Po
Tubulin,the major structural component of microtubules,has become a target for the development of anticancer agents.A se......
Aim:To investigate the effect of hyperbaric oxygen (HBO) on antitumor immune competence of mice with S-180 sarcoma.Metho......
